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2 April 1996 Photobleaching of native and exogenous (BPD-MA) fluorescence: an in-vivo tumor-bearing rat model
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Abstract
The photobleaching of the native fluorescence, as well as of the BPD-MA, an exogenous sensitizer, was measured in an in-vivo tumor bearing rat model. The photobleaching was evaluated in the time scale of seconds (approximately 0 sec - 30 sec) under continuous wave laser light irradiation at 441.6 nm. Three different sites were irradiated: the primary tumor, the mesenteric I lymph node, and the right medial iliac lymph node, at two excitation levels of 6.5 mW/mm2 (n equals 6), and approximately 35 mW/mm2 (n equals 6). Most of the fluorescence curves were adequately characterized by a biexponential decay. Increased levels of illumination were found to accelerate the photobleaching. No involvement of statistical significance of the irradiation site on the fluorescence decay was found.
© (1996) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Thanassis Papaioannou, Sandor G. Vari M.D., Vani R. Pergadia, Warren S. Grundfest M.D., and Jean-Michel I. Maarek "Photobleaching of native and exogenous (BPD-MA) fluorescence: an in-vivo tumor-bearing rat model", Proc. SPIE 2675, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V, (2 April 1996); https://doi.org/10.1117/12.237531
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