SnET2: clinical update

Nicholas J. Razum; Albert B. Snyder; Daniel R. Doiron

doi:10.1117/12.237549

2 April 1996 SnET2: clinical update

Nicholas J. Razum, Albert B. Snyder, Daniel R. Doiron

Proceedings Volume 2675, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V; (1996) https://doi.org/10.1117/12.237549
Event: Photonics West '96, 1996, San Jose, CA, United States

Abstract

Tin Ethyl Etiopurpurin, SnET2, is a synthetic chlorin analog presently in Phase-II/III clinical trials for the treatment of cutaneous cancers. Trials to date include the treatment of basal cell carcinomas, squamous cell carcinomas, breast adenocarcinomas metastatic to the chest wall and cutaneous Kaposi's sarcomas in AIDS patients. Results to date have shown significant clinical responses for drug doses between 1.0 mg/kg and 1.6 mg/kg, with the threshold for Kaposi's sarcoma being slightly higher than in other indications. Light doses from 100 J/cm² to 300 J/cm² were delivered from 24 to 72 hours post SnET2 infusion. Induced transient skin photosensitivity at the lower therapeutic doses has been mild, lasting approximately a week. Results of the Phase I and II trials are presented.

Citation Download Citation

Nicholas J. Razum, Albert B. Snyder, and Daniel R. Doiron "SnET2: clinical update", Proc. SPIE 2675, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V, (2 April 1996); https://doi.org/10.1117/12.237549

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