24 April 1996 Laser optoacoustic tomography for medical diagnostics: experiments with biological tissues
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Abstract
Feasibility of laser optoacoustic tomography to detect turbid tissues with different optical properties was experimentally investigated using real biological tissues. The following abilities of this technique were quantitatively studied: maximal depth of optoacoustic signal detection, acoustic attenuation of laser-induced pressure waves, and limit of resolution. Two types of biological tissues were used for the experiments: chicken breast muscle as a tissue with low absorption coefficient and bovine liver as a tissue with higher absorption coefficient. Tissue samples were irradiated by Q-switched Nd:YAG-laser pulses to satisfy stress-confined irradiation conditions. Laser-induced pressure waves generated in the liver samples were detected by a wide-band acoustic transducer. Pressure wave amplitude, duration, and propagation time were analyzed after the experiments. The results and theoretical calculations have demonstrated that laser-induced optoacoustic signals from biological tissues with higher absorption coefficient are measurable at depth 5 times higher than penetration depth of radiation. Low acoustic attenuation (0.006 cm-1) for laser-induced pressure waves was detected. Feasibility of the proposed imaging to detect 3 mm3 liver sample (tumor model) placed inside 80 mm-muscle tissue is demonstrated.
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Rinat O. Esenaliev, Rinat O. Esenaliev, Alexander A. Oraevsky, Alexander A. Oraevsky, Steven L. Jacques, Steven L. Jacques, Frank K. Tittel, Frank K. Tittel, } "Laser optoacoustic tomography for medical diagnostics: experiments with biological tissues", Proc. SPIE 2676, Biomedical Sensing, Imaging, and Tracking Technologies I, (24 April 1996); doi: 10.1117/12.238817; https://doi.org/10.1117/12.238817
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