Effect of physiological factors and other analytes on the determination of glucose concentration in vivo by optical absorption and scattering meaurements

Jianan Y. Qu; Brian C. Wilson

doi:10.1117/12.237593

5 April 1996 Effect of physiological factors and other analytes on the determination of glucose concentration in vivo by optical absorption and scattering meaurements

Jianan Y. Qu, Brian C. Wilson

Author Affiliations +

Proceedings Volume 2679, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases III: Optical Biopsy; (1996) https://doi.org/10.1117/12.237593
Event: Photonics West '96, 1996, San Jose, CA, United States

Abstract

Determining the concentration of glucose in vivo by near-infrared spectroscopy is complicated by the effects of optical changes caused by fluctuations in temperature, tissue water content and the concentration of other analytes. Mie theory and Monte Carlo computer simulation of light transport in optically absorbing and scattering media were used to investigate the magnitude of the changes in diffuse reflectance and transmittance from changes in glucose. Similarly, the possible interference in the glucose measurement from the other tissue parameters have been assessed and found to be significant.

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Jianan Y. Qu and Brian C. Wilson "Effect of physiological factors and other analytes on the determination of glucose concentration in vivo by optical absorption and scattering meaurements", Proc. SPIE 2679, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases III: Optical Biopsy, (5 April 1996); https://doi.org/10.1117/12.237593

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