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11 April 1996 Three-dimensional calcification reconstruction from a limited number of views
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A method has been developed to allow mammographic differential diagnosis based upon the 3- D orientation and morphology of mammary calcifications. Two to seven digital radiographs of a cluster of calcifications are acquired on a prone stereotactic breast biopsy system. The images are segmented using a recursive region-growing algorithm. Inclusion of calcific material is dependent upon local statistics calculated over a region surrounding each calcification. Segmentation is aided by correlation of the calcifications in two or more views through analysis of their positions, sizes and shapes. The location of each calcification is determined geometrically; the shape of each calcification is calculated using the segmented images and a simulated annealing reconstruction method. Image segmentation and reconstruction can be reproducibly performed with an accuracy of 0.1 mm, which is sufficient to perform 3-D morphologic analysis. Biopsy specimens and in vivo calcifications have been examined. In instances where calcifications are associated with amass, we can distinguish preferentially peripherally distributed calcifications from homogeneously distributed calcifications. We have also been able to elucidate the linear distribution of calcifications contained within the ductal system. In a preliminary ROC study involving 3 radiologists and 26 lesions (5 malignant), specificity increased when 3-D images were included in the diagnostic evaluation, resulting in an increase of Az from 0.66 to 0.88 (p equals 0.0039).
© (1996) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Andrew D. A. Maidment, Michael Albert, Emily F. Conant, and Stephen A. Feig "Three-dimensional calcification reconstruction from a limited number of views", Proc. SPIE 2708, Medical Imaging 1996: Physics of Medical Imaging, (11 April 1996);

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