Acute effects of delayed reperfusion following myocardial infarction: a 3D x-ray imaging analysis

Robert D. Simari; M. R. Bell; Y. C. Pao; B. J. Gersh; Erik Leo Ritman M.D.

doi:10.1117/12.237880

8 April 1996 Acute effects of delayed reperfusion following myocardial infarction: a 3D x-ray imaging analysis

Robert D. Simari, M. R. Bell, Y. C. Pao, B. J. Gersh, Erik Leo Ritman M.D.

Proceedings Volume 2709, Medical Imaging 1996: Physiology and Function from Multidimensional Images; (1996) https://doi.org/10.1117/12.237880
Event: Medical Imaging 1996, 1996, Newport Beach, CA, United States

Abstract

Clinical and experimental data suggest that delayed reperfusion of the infarct related artery may limit infarct expansion without increasing myocardial salvage. In order to assess the potential mechanisms involved, an acute closed chest canine model of myocardial infarction and delayed reperfusion was studied. Nineteen dogs underwent 3D computed tomography in the Dynamic Spatial Reconstructor (a fast, volume imaging, CT scanner) at baseline and three and four hours later to estimate left ventricular chamber volumes, global distensibility and regional myocardial stiffness. A control group was scanned without intervention. An occlusion group underwent four hours of coronary artery occlusion. A reperfusion group underwent three hours of coronary artery occlusion followed by one hour of reperfusion. Similar infarct sizes were seen in the occlusion and reperfusion groups. Globally reperfusion was associated with increased left ventricular end diastolic pressure and prolongation of global relaxation. Regionally reperfusion was associated with increased myocardial stiffness, intramyocardial blood volume and wall thickness within the infarct zone relative to the not reperfused myocardium.

Citation Download Citation

Robert D. Simari, M. R. Bell, Y. C. Pao, B. J. Gersh, and Erik Leo Ritman M.D. "Acute effects of delayed reperfusion following myocardial infarction: a 3D x-ray imaging analysis", Proc. SPIE 2709, Medical Imaging 1996: Physiology and Function from Multidimensional Images, (8 April 1996); https://doi.org/10.1117/12.237880

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