9 February 1996 Pore-forming proteins with built-in triggers and switches
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Genetic engineering and targeted chemical modification are being used to produce polypeptides with pore-forming activity that can be triggered or switched on-and-off by biochemical, chemical or physical stimuli. The principal target of our studies has been the (alpha) -hemolysin ((alpha) HL) from the bacterium Staphylococcus aureus. The remodeled hemolysins include protease-activated pores, metal-regulated pores, pores that are activated by chemical alkylation and pores that are turned on with light. These polypeptides have several potential applications. For example, they might serve as components of sensors or they might be useful for mediating the controlled release of encapsulated drugs.
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Hagan Bayley, Hagan Bayley, } "Pore-forming proteins with built-in triggers and switches", Proc. SPIE 2716, Smart Structures and Materials 1996: Smart Materials Technologies and Biomimetics, (9 February 1996); doi: 10.1117/12.232159; https://doi.org/10.1117/12.232159

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