For successful application of boron neutron capture therapy for treatment of cancer, it is required that the tumor receives a higher radiation dose than the surrounding healthy tissue. This is achieved by the use of appropriate boron compounds with selective accumulation or retention, and the subsequent irradiation with neutrons of suitable characteristics. The basics of these two requirement are given, and the implementation in clinical trials is discussed.
Detlef Gabel, Detlef Gabel,
"Boron neutron capture therapy: from physics to treatment", Proc. SPIE 2867, International Conference Neutrons in Research and Industry, (27 February 1997); doi: 10.1117/12.267842; https://doi.org/10.1117/12.267842