3 December 1996 Photolasertherapy for the treatment of infections in neurosurgery: experimental and clinical study
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Abstract
At the first time, the CO2 laser was utilised in infective neurosurgical pathology as a surgical cutting instrument to remove inflammatory pseudomembranes in chronic osteomyelitis, and as a vaporising instmment on the dura mater surface. Successively, the instrument, defocused and at a low power, was used for prolonged and diffuse photo coagulation ofthe surgical cavity, particularly, ofthe dural surface and ofthe osteomyelitic bone edges, with the aim to sterilise tissues. So, we saw a shortening of the average time of wound healing and a lack of recurrence of the septic pathology. Then, we have treated, with CO2 laser, intracranial infective pathology: i.e. primary abscesses, capsulated or not, circumscribed purulent encephalitis, secondary abscesses in surgical cavities (patients operated for intracranial hematomas and tumors). In these cases we have obtained a lack of septic recurrences and an improvement ofneurological post-operative course. Thank to these results, we have continued to use laser in infective pathology; for giving an experimental support to these results we have carried on researches in vivo (on the experimental animal) to see the interaction between the laser and inflammatory tissue, and in vitro (on bacterial culture: in solid and liquid media) to see the laser effect on the bacterial cell. The bacterial cell has been also sensibiized to the photo dynamic effect of the laser (Argon, He-Ne), with hematoporphyrin. The goal of these experiments is to understand the role of thermal, photochemical, and mechanic resonance laser effects in the interaction between laser radiation and bacterial cell.
© (1996) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Gian Francesco Lombard, Gian Francesco Lombard, } "Photolasertherapy for the treatment of infections in neurosurgery: experimental and clinical study", Proc. SPIE 2922, Laser Applications in Medicine and Dentistry, (3 December 1996); doi: 10.1117/12.260702; https://doi.org/10.1117/12.260702
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