3 December 1996 Repair of articular cartilage and meniscal tears by photoactive dyes: in-vivo study
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Abstract
We describe healing results of our 6 month study of a repair procedure which evokes the healing response in meniscal tears and partial thickness defects in articular cartilage by a non-thermal tissue sparing photochemical weld using 1,8-naphthalimide dyes. Welds of incisional flaps in adult sheep meniscus and femoral articular cartilage were made using the dye MBM Gold 012011012 at 12 mM in PBS, 457.9nm Argon ion laser radiation at 800 mW/cm2, 7.5 minutes with approximately 1 kg/cm2 externally applied pressure. Gross appearance of tissues in all welded knees appeared normal. Hematoxylin and eosin stained sections disclosed close bonding of welded areas and continuing healing response as cellular recruitment.
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Millard M. Judy, Robert W. Jackson, Hany R. Nosir, James Lester Matthews, David E. Lewis, Ronald E. Utecht, Dongwu Yuan, "Repair of articular cartilage and meniscal tears by photoactive dyes: in-vivo study", Proc. SPIE 2922, Laser Applications in Medicine and Dentistry, (3 December 1996); doi: 10.1117/12.260707; https://doi.org/10.1117/12.260707
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