5 December 1996 Healing of bone in the rat following surgery with the erbium-YAG laser
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Background and objectives: the aim of this study was to examine the pattern of healing in rat calvarial defects prepared with the erbium-YAG laser, using the 'guided tissue regeneration' technique. Materials and method: PTFE membranes were placed over lased skull defects, and the skin wounds sutured. Rats were killed humanely at intervals after surgery, and the skulls processed for paraffin wax histology. A further group of mature rats were also killed humanely and the calvariae removed. Slots were prepared using the erbium-YAG laser and immediately examined under the environmental scanning electron microscope (ESEM) in hydrated conditions, which avoided drying artifacts. Results: An amorphous, mineral-rich carbon layer surrounds the lased bone defect, which in the in vivo experiments was seen as a basophilic zone which was resistant to resorption.
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Mark Russell Dickinson, Mark Russell Dickinson, Hugh Devlin, Hugh Devlin, Monsour A. El Montaser, Monsour A. El Montaser, Philip Sloan, Philip Sloan, } "Healing of bone in the rat following surgery with the erbium-YAG laser", Proc. SPIE 2923, Laser-Tissue Interaction and Tissue Optics II, (5 December 1996); doi: 10.1117/12.260729; https://doi.org/10.1117/12.260729

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