Cyclic accumulation strategies for polyphasic photoimmunotherapy using the biotin-avidin system

Joerg G. Moser; Marina V. Demcheva; Alexander P. Savitzki; Gelii V. Ponomarev; Eugeny A. Lukyanets

doi:10.1117/12.260750

4 December 1996 Cyclic accumulation strategies for polyphasic photoimmunotherapy using the biotin-avidin system

Joerg G. Moser, Marina V. Demcheva, Alexander P. Savitzki, Gelii V. Ponomarev, Eugeny A. Lukyanets

Proceedings Volume 2924, Photochemotherapy: Photodynamic Therapy and Other Modalities II; (1996) https://doi.org/10.1117/12.260750
Event: BiOS Europe '96, 1996, Vienna, Austria

Abstract

Polybiotinylated porphyrinoids and linear alkyl-dibiotins were used to describe accumulation behavior of avidin and POD-labelled avidin on tumor cells preincubated with biotinylated monoclonal antibodies. The accumulation behavior followed more a liner than a formerly postulated branched pattern. This allows for us to calculate necessary repeats of accumulation in order to acquire the necessary amount of sensitizer molecules per tumor cell at low concentration of tumor specific marker molecules at the cell surface.

Citation Download Citation

Joerg G. Moser, Marina V. Demcheva, Alexander P. Savitzki, Gelii V. Ponomarev, and Eugeny A. Lukyanets "Cyclic accumulation strategies for polyphasic photoimmunotherapy using the biotin-avidin system", Proc. SPIE 2924, Photochemotherapy: Photodynamic Therapy and Other Modalities II, (4 December 1996); https://doi.org/10.1117/12.260750

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