4 December 1996 Laser fluorescence investigation of chlorin e6 pharmacokinetics
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The pharmacokinetic behavior of chlorin e6 in different organs and tumor tissues of rats infected with Sarcoma-45 has been investigated with help of the fiber-optic spectrofluorometer at excitation by harmonics of YAG:Nd laser ((lambda) equals 355, 532 and 660 nm). The most intensive chlorine e6 fluorescence in tumor tissue was observed in 18 hours after pigment injection. The optimal time of fluorescence diagnosis has been determined (in 27 hours after pigment injection). The maximum of the tumor-to- normal tissue ratio of fluorescence was equal 10 at 666 nm. The rates of the accumulation and elimination of chlorin e6 in the skin, hypodermic tissues and tumors of rats were determined in vivo.
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Vladimir A. Hovanessian, Vladimir A. Hovanessian, Asatour Lalaian, Asatour Lalaian, Grigor Gyulkhandanyan, Grigor Gyulkhandanyan, "Laser fluorescence investigation of chlorin e6 pharmacokinetics", Proc. SPIE 2924, Photochemotherapy: Photodynamic Therapy and Other Modalities II, (4 December 1996); doi: 10.1117/12.260784; https://doi.org/10.1117/12.260784

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