Quantification of hemoglobin saturation on tissue phantom using phase-modulation spectroscopy

Congwu Du; Hanli Liu; Britton Chance

doi:10.1117/12.260836

6 December 1996 Quantification of hemoglobin saturation on tissue phantom using phase-modulation spectroscopy

Congwu Du, Hanli Liu, Britton Chance

Proceedings Volume 2925, Photon Propagation in Tissues II; (1996) https://doi.org/10.1117/12.260836
Event: BiOS Europe '96, 1996, Vienna, Austria

Abstract

Int his article, we analytically present the influence of the systematic error due to the theoretical assumptions on the blood oxygenation determination using a 'phase-only' dual-wavelength phase-modulation spectroscopy (PMS). To approach an accurate quantification of hemoglobin saturation, an empirical method to experimentally acquire the initial phase-shift value in oxygenation quantification form PMS data is investigated on blood-perfused phantom. Our results show that the quantification error of blood oxygenation determination can be substantially compensated by using the acquired (theta) ₀^(lambda ) method and is confirmed to be less than 10 percent by comparison with the measured results of the Pt electrode.

Citation Download Citation

Congwu Du, Hanli Liu, and Britton Chance "Quantification of hemoglobin saturation on tissue phantom using phase-modulation spectroscopy", Proc. SPIE 2925, Photon Propagation in Tissues II, (6 December 1996); https://doi.org/10.1117/12.260836

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