Characterization of human skin using optical coherence tomography

Valentin M. Gelikonov; Alexander M. Sergeev; Grigory V. Gelikonov; Felix I. Feldchtein; Natalia D. Gladkova; John Ioannovich; K. Frangia; T. Pirza; V. Zhegalov; D. Aleinik; I. Vazina; Ludmila Snopova; Ioannis Antoniou

doi:10.1117/12.260644

11 December 1996 Characterization of human skin using optical coherence tomography

Valentin M. Gelikonov, Alexander M. Sergeev, Grigory V. Gelikonov, Felix I. Feldchtein, Natalia D. Gladkova, John Ioannovich, K. Frangia, T. Pirza, V. Zhegalov, D. Aleinik, I. Vazina, Ludmila Snopova, Ioannis Antoniou

Author Affiliations +

Proceedings Volume 2927, Optical and Imaging Techniques for Biomonitoring II; (1996) https://doi.org/10.1117/12.260644
Event: BiOS Europe '96, 1996, Vienna, Austria

Abstract

We report the results of clinical test of a compact, fast- scanning OCT device, elaborated in the Institute of Applied Physics Russian Academy of Sciences. The device is based on a polarization-preserving optical fiber. Michelson interferometer with an integrated unit for fast electro- optic scanning in the depth of the investigated tissue. An essential advantage of the polarization-preserving fiber interferometer scheme consists in employing a flexible fiber cable in the sample arm. This is principal for clinical applications of the OCT, first of all in dermatology and endoscopy studying of internal organs. The compact OCT device includes a 1.5 mW superluminescent source of radiation at the wavelength of 0.83 mcm with the 30 nm spectral width. It enables to produce 200 by 200 images for approximately 1 s acquisition time. Clinical tests of the device have been focused on monitoring of pathological and postoperative states and burns of human skin in vivo and in vitro and determining optical characteristics (refraction index, scattering coefficients) of human tissues. Parallel histological study of postoperative specimens has been carried out. Recently developed OCT device for simultaneous dual-wavelength imaging will allow to distinguish better absorbing and scattering structures and differentiate melanocytic skin lesions including tumors.

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Valentin M. Gelikonov, Alexander M. Sergeev, Grigory V. Gelikonov, Felix I. Feldchtein, Natalia D. Gladkova, John Ioannovich, K. Frangia, T. Pirza, V. Zhegalov, D. Aleinik, I. Vazina, Ludmila Snopova, and Ioannis Antoniou "Characterization of human skin using optical coherence tomography", Proc. SPIE 2927, Optical and Imaging Techniques for Biomonitoring II, (11 December 1996); https://doi.org/10.1117/12.260644

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