Speckle intensity correlation analysis as a method of tissue structure imaging

Dmitry A. Zimnyakov; Kirill V. Larin; Alexey A. Mishin; Valery V. Tuchin

doi:10.1117/12.260645

11 December 1996 Speckle intensity correlation analysis as a method of tissue structure imaging

Dmitry A. Zimnyakov, Kirill V. Larin, Alexey A. Mishin, Valery V. Tuchin

Author Affiliations +

Proceedings Volume 2927, Optical and Imaging Techniques for Biomonitoring II; (1996) https://doi.org/10.1117/12.260645
Event: BiOS Europe '96, 1996, Vienna, Austria

Abstract

Correlation analysis of the intensity fluctuations due to the laser light scattering is one of the prospective methods for tissue structure analysis and imaging. For steady- structure scattering media these fluctuations can be produced by laser beam scanning. Asymptotic behavior of the intensity autocorrelation and structure functions caused by small-scale peculiarities of the tissue scattering structure can be described with the usage of exponential factor. In our work this parameter is proposed as the visualization one for tissue structure imaging. Some experimental results obtained for human epidermis and sclera samples using this technique are discussed. Two-dimensional images of the healthy and diseased (psoriatic) human epidermis are presented. Computer simulation of the imaging reconstruction procedure had been carried out for different models of the scattered light intensity fluctuations. Presented results allow us to recommend similar methods (spatial speckle correlometry) as one of the methods for tissue structure monitoring.

Citation Download Citation

Dmitry A. Zimnyakov, Kirill V. Larin, Alexey A. Mishin, and Valery V. Tuchin "Speckle intensity correlation analysis as a method of tissue structure imaging", Proc. SPIE 2927, Optical and Imaging Techniques for Biomonitoring II, (11 December 1996); https://doi.org/10.1117/12.260645

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