A fusion of two independent but complementary three- dimensional imaging techniques is proposed for detecting drugs in containers, cargo, mail and luggage. The containers, cargo, mail and/or luggage are scanned using a combined neutron and gamma ray source. A detector that can detect both neutrons and gamma rays is used to produce three dimensional images from both signals. The two images will be combined and analyzed by a fast host computer to detect drugs that may be concealed in the container, cargo and/or luggage. The two independent signatures from both neutrons and gamma rays, when analyzed simultaneously, may help determine the type of concealed material inside the containers. Containers, cargo and luggage are filled with a large variety of materials. Imaging them only in two dimensions may result in a poor contraband detection probability as different materials may shield each other. Therefore, a true three-dimensional imaging system is proposed, where the individual items inside the container or cargo can be resolved. This is expected to lead to reliable identification of the drugs even in small quantities. Such a system will also pinpoint the location of the suspected item and help expedite inspection by law enforcement agents. The proposed detection system produces two complementary three- dimensional images of the containers, cargo and/or luggage. These images are combined and analyzed by a specially developed algorithm to identify and locate the contraband automatically.