The multi-angle imaging spectroradiometer (MISR) will provide global data sets from Earth orbit using nine pushbroom cameras, each viewing in a fixed, unique direction. Data will be acquired for day-lit portions of the orbit at an average rate of 3.3 Mbits s-1 for the entire six year mission. Automated ground processing will make use of the instrument radiometric, spectral, and geometric calibrations, to produce registered images at the nine view angles. This, the Level 1 product, provides top- of-atmosphere scene radiances, weighted by the spectral band profile for the instrument. Initially, processing will proceed with pre-flight determined radiometric response coefficients. In-flight radiometric calibration of the sensor will then provide monthly updates to these coefficients, to account for degradation which may occur during the mission. THe spectral response profiles are invariant in time, and are provided only by the pre-flight measurements. These include an out-of-band spectral calibration of each channel. These spectral data are used as input to the radiometric calibration of the instrument, and also to produce certain Level 2 products for which an out- of-band correction is made. This paper describes the calibration program, with emphasis on results from the recently completed pre-flight calibration.