In-vivo investigations on interstitial Ho:YAG laser therapy

Ronald Sroka; Aaron P. Perlmutter M.D.; T. Pongratz; Rolf Muschter M.D.

doi:10.1117/12.275026

22 May 1997 In-vivo investigations on interstitial Ho:YAG laser therapy

Ronald Sroka, Aaron P. Perlmutter M.D., T. Pongratz, Rolf Muschter M.D.

Proceedings Volume 2970, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII; (1997) https://doi.org/10.1117/12.275026
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

Laser induced interstitial thermotherapy is a new minimally invasive procedure for the treatment of benign prostatic hyperplasia. In this study Ho:YAG laser induced lesions were investigated on liver, kidney and prostates of canines. While the dependency of the induced lesions on the energy/pulse at a constant mean power had been investigated on the liver, the dependency on the pulse duration was studied on the kidney. Additionally the dependency of the lesions induced on the total applied energy at optimized parameters had been determined in prostate tissue. In all experiments it could be demonstrated that interstitial pulsed Ho:YAG irradiation resulted in a cavity surrounded by a coagulation zone. The results show that changing the pulse duration by a factor of two or changing the energy/pulse at a constant mean power result in no significant alteration of the lesions sizes. These experimental findings may offer new treatment modalities with respect to interstitial laser therapy of BPH without damaging the urethra.

Citation Download Citation

Ronald Sroka, Aaron P. Perlmutter M.D., T. Pongratz, and Rolf Muschter M.D. "In-vivo investigations on interstitial Ho:YAG laser therapy", Proc. SPIE 2970, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII, (22 May 1997); https://doi.org/10.1117/12.275026

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