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22 May 1997 Photoeradication and imaging of atheromatous plaque with texaphyrins
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Abstract
Cardiovascular disease is the chief cause of death in the western world. Lutetium texaphyrin (PCI-0123) is a pure, synthetic, aqueous-soluble macrocycle that localizes in both cancerous lesions and atheromatous plaque. The lutetium texaphyrin complex is a potent photosensitizer in vivo, where it is activated by tissue-penetrating far red light (720 - 760 nm). Patient diagnosis and treatment planning are possible with PCI-0123 fluorescence imaging. In this study the localization and selective eradication of atheromatous plaque using PCI-0123 and photoangioplasty are discussed.
© (1997) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Kathryn W. Woodburn, Fan Qing, David Kessel, and Stuart W. Young M.D. "Photoeradication and imaging of atheromatous plaque with texaphyrins", Proc. SPIE 2970, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII, (22 May 1997); https://doi.org/10.1117/12.275065
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