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8 May 1997 Tumor detection in HpD-sensitized mice with fluorescence lifetime imaging
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Abstract
Three time-delayed fluorescence images were used to calculate the spatial distribution of the fluorescence decay time in tumor-bearing mice sensitized with Hematoporphyrin Derivative (HpD). This allowed us to observe that the drug has a significantly longer fluorescence lifetime when it is incorporated in neoplastic tissues with respect to healthy surrounding ones. The imaging technique can be applied noninvasively in vivo in real time. Its diagnostic potential was tested on two murine tumor models after sensitization with low doses of HpD. In all the experimental conditions considered, the tumor could be easily identified in the lifetime images. Images were acquired also after removal of the skin overlying the tumor mass. Removal of the skin led to higher values of the lifetime contrast and allowed an even easier tumor localization.
© (1997) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Rinaldo Cubeddu, Gianfranco L. Canti, Antonio Pifferi, Paola Taroni, and Gianluca Valentini "Tumor detection in HpD-sensitized mice with fluorescence lifetime imaging", Proc. SPIE 2972, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy VI, (8 May 1997); https://doi.org/10.1117/12.273499
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