In-vivo confocal scanning laser ophthalmoscopic characterization of retinal pathology in a small-eye-animal model

Harry Zwick; Rowe Elliot; Steven T. Schuschereba; David J. Lund; Bruce E. Stuck

doi:10.1117/12.275253

2 May 1997 In-vivo confocal scanning laser ophthalmoscopic characterization of retinal pathology in a small-eye-animal model

Harry Zwick, Rowe Elliot, Steven T. Schuschereba, David J. Lund, Bruce E. Stuck

Author Affiliations +

Proceedings Volume 2974, Laser and Noncoherent Ocular Effects: Epidemiology, Prevention, and Treatment; (1997) https://doi.org/10.1117/12.275253
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

We have used confocal scanning laser ophthalmoscopy (CSLO) to evaluate acute laser retinal injury in a small eye animal model. THe snake eye is optically unique, combining a high numerical aperture with a clear ocular media and a cornea covered with a hard dry spectacle. These optical qualities allow detailed resolution of photoreceptors, retinal nerve fiber, and retinal capillary blood cells in an intact vertebrate eye. We demonstrated that acute laser exposures capable of damaging the photoreceptor matrix may also alter blood flow at more anterior levels of the retina. Changes in photoreceptor density and orientation were indicated in the early post exposure seconds at high dose acute Argon laser exposures. An increase in photoreceptor reflectivity was observed in surviving photoreceptors and was enhanced with a near IR CSLO imaging source. Q-switched exposure failed to show this enhancement, possibly because of greater subchoroidal involvement associated with acoustic damage processes.

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Harry Zwick, Rowe Elliot, Steven T. Schuschereba, David J. Lund, and Bruce E. Stuck "In-vivo confocal scanning laser ophthalmoscopic characterization of retinal pathology in a small-eye-animal model", Proc. SPIE 2974, Laser and Noncoherent Ocular Effects: Epidemiology, Prevention, and Treatment, (2 May 1997); https://doi.org/10.1117/12.275253

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KEYWORDS

Reflectivity

Blood

Eye

Injuries

Retina

Confocal microscopy

In vivo imaging

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