Determination of tissue properties by immersion in a matched scattering fluid

Xingkun Wu; Lesli Stinger; Gregory W. Faris

doi:10.1117/12.280258

18 August 1997 Determination of tissue properties by immersion in a matched scattering fluid

Xingkun Wu, Lesli Stinger, Gregory W. Faris

Proceedings Volume 2979, Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II; (1997) https://doi.org/10.1117/12.280258
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

We used frequency-domain measurements with immersion in a matched scattering medium to measure the optical properties of tissue. This approach reduces the effects of boundaries and geometry on the measurements. The diffusion equation, typically used as the basis for determining tissue optical properties, is not valid near a boundary. By immersing the tissue in a scattering medium with nearly the same scattering and absorption coefficients, the boundary effects are greatly reduced and the measurement conditions nearly approximate that in an infinite medium. Also, the measurement is made as a differential against a true homogeneous medium for which the scattering and absorption coefficients can be obtained quite accurately. We demonstrated this approach, using frequency- domain measurements to determine absorption and scattering coefficients of living tissue immersed in diluted intralipid, Ropaque, or milk. Previous approaches to determine optical properties in the frequency-domain used multiple path lengths or multiple frequencies. Immersion is a third frequency-domain approach.

Citation Download Citation

Xingkun Wu, Lesli Stinger, and Gregory W. Faris "Determination of tissue properties by immersion in a matched scattering fluid", Proc. SPIE 2979, Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II, (18 August 1997); https://doi.org/10.1117/12.280258

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