18 August 1997 Functional near-infrared imager
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Abstract
We developed a continuous wave (cw) light imaging probe which includes 9 light sources and four pairs detectors (each pair has one 850 nm filtered detector and one 760 nm filtered detector). The light sources are controlled by a computer and the signals from the detectors are converted and processed in the computer. There are 16 measurement sections and total detection area is 9 cm multiplied by 4 cm which can be scanned every 8 seconds. The detector-source uses 2.5 cm spacing. In this study, we present the noise, drift, detectivity and spatial resolution test results of the imager. Changes of oxygenation and blood volume in about 2 cm depth from the surface of brain model can be detected. The temporal resolution is 8 seconds and spatial resolution is about 2 cm. The detectivity of OD changes can reach 0.008. With this cw imaging probe, we measured motor function in motor cortex area, visual function in occipital area, and cognitive activity in frontal forehead area of the human brian when the subjects are stimulated by moving fingers, viewing a flashing light and doing an analogy test, respectively. The experimental results show that the cw imaging probe can be used for functional images of brain activity, base upon changes of oxygenation and blood volume due to the stimulus.
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Qingming Luo, Qingming Luo, Shoko Nioka, Shoko Nioka, Britton Chance, Britton Chance, "Functional near-infrared imager", Proc. SPIE 2979, Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II, (18 August 1997); doi: 10.1117/12.280228; https://doi.org/10.1117/12.280228
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