18 August 1997 Measurement of absorption coefficients in small volumes of highly scattering media
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Abstract
The measurement of absorption coefficients in small volumes of turbid media using endoscope-compatible probes potentially has many applications including the assessment of concentrations of PDT and chemotherapy drugs in tissue. Methods for determination of absorption coefficients in small volumes for which the diffusion approximation is invalid have not previously been developed. Our aim its to develop a technique for measuring small changes in absorption based on broad wavelength, cw measurements. Our primary approach is to develop phenomenological algorithms based on the results of Monte Carlo simulations of light transport. The algorithms are tested using tissue phantoms to which known amounts of an absorber have been added. Results indicate that for some light excitation and collection geometries the average pathlength for the collected light does not depend on the scattering properties for the range of scattering parameters expected in tissue.
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Judith R. Mourant, Judith R. Mourant, Irving J. Bigio, Irving J. Bigio, Darren A. Jack, Darren A. Jack, Tamara M. Johnson, Tamara M. Johnson, Heather D. Miller, Heather D. Miller, } "Measurement of absorption coefficients in small volumes of highly scattering media", Proc. SPIE 2979, Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II, (18 August 1997); doi: 10.1117/12.280257; https://doi.org/10.1117/12.280257
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