18 August 1997 Photon migration imaging using multipixel measurements
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Abstract
In order to reconstruct images of heterogeneities embedded deep within tissues, multiple-pixel measurements of frequency domain photon migration are necessary. Typically, these measurements are performed at multiple locations on the periphery of the sample using individual fiber optics. However, measurements using multiple fiber optics are both tedious and time consuming, especially as one increases spatial measurement resolution. In our research, we acquire multi-pixel measurements by employing a gain-modulated image intensified CCD camera and near infrared milliwatt laser diodes to monitor the propagation characteristics of sinusoidally modulated light as it passes through tissue-like phantoms containing 0.5% intralipid solutions. Our results show that images of millimeter sized absorbing objects located greater than 1 cm inside an ideal tissue phantom an be successfully obtained. In addition, we have been able to generate fluorescent images locating portions of micromolar concentrations of indocyanine green embedded within an intralipid solution contained within a glass cylindrical vessel (10 mm by 4 mm diameter).
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Tamara L. Troy, Tamara L. Troy, Jeffery S. Reynolds, Jeffery S. Reynolds, Eva Marie Sevick-Muraca, Eva Marie Sevick-Muraca, } "Photon migration imaging using multipixel measurements", Proc. SPIE 2979, Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II, (18 August 1997); doi: 10.1117/12.280237; https://doi.org/10.1117/12.280237
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