2 May 1997 LDF assessment of tumor blood flow and flux motions in photodynamic therapy
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In patients with basal cell carcinoma (BCC) skin microcirculation was measured by the laser Doppler flowmeter (LDF). Spectral analysis of LDF-signal based on fast Fourier transform enables us to evaluate an amplitude and predominated frequency of flux motions in the next diapasons: (alpha) -rhythm, (beta) -rhythm, (gamma) -rhythm, high-frequency rhythm and cardiorhythm. For photodynamic therapy (PDT) hematoporphyrin derivative was administrated intravenously in dosage 1-2 mg/Kg. In 24 hours after that all patients were exposed to the red laser irradiation in dose 200-300 J/cm2. The microcirculation level in BCC was higher than in the plots of healthy skin. Exactly after PDT the marked decrease of microcirculation up to 4.7 +/- 0.63 a.u. associated with photoinduced stasis took place in the tumor. Spectral analysis of flux motions demonstrated a significant inhibition of (alpha) -, (beta) -rhythms and amplification of HF- and CF-rhythm In 1 week after PDT we observed a gradual restoration of microcirculation in the zone of PDT skin injury that followed a wound healing process.
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Valentine I. Kozlov, Valentine I. Kozlov, Oleg Alexandrov Terman, Oleg Alexandrov Terman, } "LDF assessment of tumor blood flow and flux motions in photodynamic therapy", Proc. SPIE 2982, Optical Diagnostics of Biological Fluids and Advanced Techniques in Analytical Cytology, (2 May 1997); doi: 10.1117/12.273612; https://doi.org/10.1117/12.273612

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