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10 April 1997Holographic interferometry for detection of breast lesions
Holographic Interferometry (HI) has been utilized in industry to inspect material for defects or the dynamic characteristics of a laminated structure. Application of the HI technique for biomedical diagnostic instrumentation was also reported. For detection of breast lesions, which could lead to breast cancer, we have utilized the HI technique to create a superficial fringe contour distortion over the underlying lesion. In the HI technique, an appropriate stressing mechanism is crucial to obtain proper density and contrast of fringe patterns. To apply pressure as the stressing mechanism, we have designed the Lucite pressure chamber to enclose both of the subject's breasts. Preliminary results have demonstrated the feasibility of fringe distortions occurring around breast lesions. The location of the possible lesions have been compared with an X-ray mammography.
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HyunDae Hong, Daniel B. Sheffer, C. William Loughry, "Holographic interferometry for detection of breast lesions," Proc. SPIE 3011, Practical Holography XI and Holographic Materials III, (10 April 1997); https://doi.org/10.1117/12.271345