25 April 1997 Autoradiographic-based phantoms for emission tomography
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In the development of reconstruction algorithms in emission computed tomography (ECT), digital phantoms designed to mimic the presumed spatial distribution of radionuclide activity in a human are extensively used. Given the low spatial resolution in ECT, it is usually presumed that a crude phantom, usually with a constant activity level within an anatomically derived region, is sufficiently realistic for testing. Here, we propose that phantoms may be improved by assigning biologically realistic patterns of activity in more precisely delineated regions. Animal autoradiography is proposed as a source of realistic activity and anatomy. We discus the basics of radiopharmaceutical autoradiography and discuss aspects of using such data for a brain phantom. A few crude simulations with brain phantoms derived from animal data are shown.
© (1997) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Gene R. Gindi, Gene R. Gindi, Doug Dougherty, Doug Dougherty, Ing-Tsung Hsiao, Ing-Tsung Hsiao, Anand Rangarajan, Anand Rangarajan, } "Autoradiographic-based phantoms for emission tomography", Proc. SPIE 3034, Medical Imaging 1997: Image Processing, (25 April 1997); doi: 10.1117/12.274126; https://doi.org/10.1117/12.274126

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