11 February 1997 Mathematical modeling of cell proliferation dynamics in psoriatic epidermis sensitized by the furocoumarins under UVA radiation
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Proceedings Volume 3053, Nonlinear Dynamics and Structures in Biology and Medicine: Optical and Laser Technologies: International Workshop; (1997); doi: 10.1117/12.266242
Event: International Workshop on Nonlinear Dynamics and Structures in Biology and Medicine: Optical and Laser Technologies, 1996, Saratov, Russian Federation
Abstract
In the work the mathematical model is presented which describes the processes in the epidermis sensitized by the furocoumarins under UVA-radiation. The model describes the processes at three levels: molecular (the photochemical transformations of the psoralen molecules and their reactions with the DNA-molecules), cellular (proliferation, differentiation and repairing of injuries), and tissue (humoral regulation, space-time cell dynamics in the epidermis). The results of the numerical simulations of both the latent period and psoriasis manifestation are given. The therapeutical effect of the UV-radiation is considered in the framework of the model.
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Pavel V. Baskakov, Mikhail M. Stolnitz, "Mathematical modeling of cell proliferation dynamics in psoriatic epidermis sensitized by the furocoumarins under UVA radiation", Proc. SPIE 3053, Nonlinear Dynamics and Structures in Biology and Medicine: Optical and Laser Technologies: International Workshop, (11 February 1997); doi: 10.1117/12.266242; https://doi.org/10.1117/12.266242
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KEYWORDS
Mathematical modeling

Molecules

Receptors

Cancer

Process modeling

Skin

Control systems

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