Mathematical modeling of cell proliferation dynamics in psoriatic epidermis sensitized by the furocoumarins under UVA radiation

Pavel V. Baskakov; Mikhail M. Stolnitz

doi:10.1117/12.266242

11 February 1997 Mathematical modeling of cell proliferation dynamics in psoriatic epidermis sensitized by the furocoumarins under UVA radiation

Pavel V. Baskakov, Mikhail M. Stolnitz

Author Affiliations +

Proceedings Volume 3053, Nonlinear Dynamics and Structures in Biology and Medicine: Optical and Laser Technologies: International Workshop; (1997) https://doi.org/10.1117/12.266242
Event: International Workshop on Nonlinear Dynamics and Structures in Biology and Medicine: Optical and Laser Technologies, 1996, Saratov, Russian Federation

Abstract

In the work the mathematical model is presented which describes the processes in the epidermis sensitized by the furocoumarins under UVA-radiation. The model describes the processes at three levels: molecular (the photochemical transformations of the psoralen molecules and their reactions with the DNA-molecules), cellular (proliferation, differentiation and repairing of injuries), and tissue (humoral regulation, space-time cell dynamics in the epidermis). The results of the numerical simulations of both the latent period and psoriasis manifestation are given. The therapeutical effect of the UV-radiation is considered in the framework of the model.

Citation Download Citation

Pavel V. Baskakov and Mikhail M. Stolnitz "Mathematical modeling of cell proliferation dynamics in psoriatic epidermis sensitized by the furocoumarins under UVA radiation", Proc. SPIE 3053, Nonlinear Dynamics and Structures in Biology and Medicine: Optical and Laser Technologies: International Workshop, (11 February 1997); https://doi.org/10.1117/12.266242

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available