The Information Systems Office (ISO) at DARPA develops, applies, integrates, and transitions information technology and systems to enable domination of the battlespace. To that end, ISO is engaged in three thrusts: comprehensive battlespace awareness; intelligent and timely force management and battle execution, and; realistic and affordable simulation for training, mission rehearsal, and course of action evaluation. In each thrust, ISO concentrates on enduring and future threats and solutions. The development approach involves creating the next generation of infrastructure, technology, and applications to build, sustain, and maintain a tightly-coupled system of systems. ISO information systems drive evolving concepts and doctrine for implementing a new warfare paradigm in which knowledge, not mass and fire power, is key to battlespace dominance across the ever-expanding spectrum of conflict. In all its operations, ISO programs foster cost effective acquisition of follow-on development and production systems. The following presents the goals of each ISO thrust: battlespace awareness; force management; and simulation.