Fluorescent x-ray computed tomography to visualize specific material distribution

Tohoru Takeda; Tetsuya Yuasa; Atsunori Hoshino; Masahiro Akiba; Akira Uchida; Masahiro Kazama; Kazuyuki Hyodo; F. Avraham Dilmanian; Takao Akatsuka; Yuji Itai

doi:10.1117/12.279355

24 October 1997 Fluorescent x-ray computed tomography to visualize specific material distribution

Tohoru Takeda, Tetsuya Yuasa, Atsunori Hoshino, Masahiro Akiba, Akira Uchida, Masahiro Kazama, Kazuyuki Hyodo, F. Avraham Dilmanian, Takao Akatsuka, Yuji Itai

Author Affiliations +

Proceedings Volume 3149, Developments in X-Ray Tomography; (1997) https://doi.org/10.1117/12.279355
Event: Optical Science, Engineering and Instrumentation '97, 1997, San Diego, CA, United States

Abstract

Fluorescent x-ray computed tomography (FXCT) is being developed to detect non-radioactive contrast materials in living specimens. The FXCT systems consists of a silicon channel cut monochromator, an x-ray slit and a collimator for detection, a scanning table for the target organ and an x-ray detector for fluorescent x-ray and transmission x-ray. To reduce Compton scattering overlapped on the K(alpha) line, incident monochromatic x-ray was set at 37 keV. At 37 keV Monte Carlo simulation showed almost complete separation between Compton scattering and the K(alpha) line. Actual experiments revealed small contamination of Compton scattering on the K(alpha) line. A clear FXCT image of a phantom was obtained. Using this system the minimal detectable dose of iodine was 30 ng in a volume of 1 mm³, and a linear relationship was demonstrated between photon counts of fluorescent x-rays and the concentration of iodine contrast material. The use of high incident x-ray energy allows an increase in the signal to noise ratio by reducing the Compton scattering on the K(alpha) line.

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Tohoru Takeda, Tetsuya Yuasa, Atsunori Hoshino, Masahiro Akiba, Akira Uchida, Masahiro Kazama, Kazuyuki Hyodo, F. Avraham Dilmanian, Takao Akatsuka, and Yuji Itai "Fluorescent x-ray computed tomography to visualize specific material distribution", Proc. SPIE 3149, Developments in X-Ray Tomography, (24 October 1997); https://doi.org/10.1117/12.279355

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