Localization of porphyrine amino acid derivatives in superficial tumors using laser-induced fluorescence

Miroslaw Kwasny; Zygmunt Mierczyk; Andrzej Gietka; Alfreda Graczyk; Janusz Domaniecki

doi:10.1117/12.292852

23 October 1997 Localization of porphyrine amino acid derivatives in superficial tumors using laser-induced fluorescence

Miroslaw Kwasny, Zygmunt Mierczyk, Andrzej Gietka, Alfreda Graczyk, Janusz Domaniecki

Author Affiliations +

Proceedings Volume 3188, Laser Technology V: Applications in Medicine and Ecology; (1997) https://doi.org/10.1117/12.292852
Event: Laser Technology V, 1996, Szczecin, Poland

Abstract

The results of examinations of accumulation of bis-1(I- alanylo-N)-ethylo-deuteroprotoporfiryne (Ala-PP) in healthy tissues and superficial tumors of 10 patients are presented. Fluorescence imaging was carried out by means of a CCD camera, coupled with an image amplifier. As an excitation source a titanium laser was used. Contrary to healthy tissues, the tumor ones are characterized by the slight decrease in Ala-PP concentration during several days after injection of preparation what enables initial determination of a tissue character and next application of a selective therapeutic irradiation.

Citation Download Citation

Miroslaw Kwasny, Zygmunt Mierczyk, Andrzej Gietka, Alfreda Graczyk, and Janusz Domaniecki "Localization of porphyrine amino acid derivatives in superficial tumors using laser-induced fluorescence", Proc. SPIE 3188, Laser Technology V: Applications in Medicine and Ecology, (23 October 1997); https://doi.org/10.1117/12.292852

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