Dynamics of photosensitizers in cell cultures and nonanimal in-vivo systems

Angelika C. Rueck; Nermin Akguen; K. Heckelsmiller; Gerd C. Beck; Karin Kunzi-Rapp

doi:10.1117/12.297787

29 December 1997 Dynamics of photosensitizers in cell cultures and nonanimal in-vivo systems

Angelika C. Rueck, Nermin Akguen, K. Heckelsmiller, Gerd C. Beck, Karin Kunzi-Rapp

Proceedings Volume 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III; (1997) https://doi.org/10.1117/12.297787
Event: BiOS Europe '97, 1997, San Remo, Italy

Abstract

The biochemical background of photodynamic therapy is only partly resolved. The biodynamic, which is shown to be different for lipophilic and hydrophilic photosensitizers influences the photodynamic efficiency. A complex cellular and subcellular localization and relocalization of the drugs is not only observed with varying incubation time but also during the light induced process. The dynamic behavior of lipophilic and hydrophilic phthalocyanines in cell cultures and non animal in vivo systems will be summarized within the presentation. As in vivo system the chorioallantoic membrane (CAM) of fertilized eggs was used. The dynamic behavior was observed with a confocal laser scanning microscope.

Citation Download Citation

Angelika C. Rueck, Nermin Akguen, K. Heckelsmiller, Gerd C. Beck, and Karin Kunzi-Rapp "Dynamics of photosensitizers in cell cultures and nonanimal in-vivo systems", Proc. SPIE 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III, (29 December 1997); https://doi.org/10.1117/12.297787

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