29 December 1997 Modulation of Photofrin II accumulation in C6 glioma cells by stimulation of beta-adrenergic receptors
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Abstract
The influence of drugs acting as (beta) -receptors agonists or antagonists on the uptake of Photofrin II in C6 glioma cultured cells was studied by microspectrofluorometric analysis. The pharmacological effect was evaluated on the semiconfluently grown cells, characterized by a long lasting uptake process and higher values of fluorescence intensity with respect to the solitary ones. Isoproterenol treatments resulted in a significant enhancement (by 50%) of the intracellular fluorescence signal of Photofrin II. This effect was hindered by contemporary treatments with equimolar alprenolol or propranolol, two (beta) -receptor antagonists, indicating a specific effect of isoproterenol. Both pharmacological activation of vesicular transport and changes in the membrane physical-chemico properties can explain the effects induced by drugs interacting with (beta) -receptor.
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Anna Cleta Croce, Anna Cleta Croce, V. Mares, V. Mares, V. Lisa, V. Lisa, D. Krajci, D. Krajci, Giovanni F. Bottiroli, Giovanni F. Bottiroli, } "Modulation of Photofrin II accumulation in C6 glioma cells by stimulation of beta-adrenergic receptors", Proc. SPIE 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III, (29 December 1997); doi: 10.1117/12.297827; https://doi.org/10.1117/12.297827
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