29 December 1997 New biotinylated phthalocyanines for the photodynamic therapy of cancer
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Abstract
Suitable substituted phthalocyanines are promising and widely investigated photosensitizers (PS) for the photodynamic therapy of cancer (PDT). However, selective accumulation of the PSs in tumor tissues, avoiding contamination of healthy tissues, is still an unsolved central problem. We present first results on the synthesis of new biotinylated phthalocyanines as potentially selective photosensitizers when applied in a polyphasic tumor targeting (tumor cell plus first step: biotinylated/monoclonal antibody, second step: streptavidin, and third step: biotinylated PS). The binding and the photodynamic activity of biotinylated PS in this three step model is shown in tumor cell lines.
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Andreas Hirth, Bernd Bartik, Tatjana Bogdahn-Rai, Dieter Woehrle, Sepp Kaul, "New biotinylated phthalocyanines for the photodynamic therapy of cancer", Proc. SPIE 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III, (29 December 1997); doi: 10.1117/12.297819; https://doi.org/10.1117/12.297819
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