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29 December 1997 Pharmacokinetics evaluation of 132-hydroxy-bacteriopheophorbid-a methyl ester and octa-alpha-butyloxy-zinc phthalocyanine for future application in PDT
M. Samy Ismail, Cathrin Dressler, Beate Roeder, H. Weitzel, Hans-Peter Berlien
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Proceedings Volume 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III; (1997) https://doi.org/10.1117/12.297821
Event: BiOS Europe '97, 1997, San Remo, Italy
Abstract
The pharmacokinetics of 132-hydroxy-bacteriopheophorbid-a methyl ester (132-OH-BPME) and octa-(alpha) -butyloxy-zinc phthalocyanine (8-(alpha) -bo-Zn-Pc) were studied in mice bearing Lewis lung carcinoma. Absorption spectroscopy was used to measure the photosensitizers concentrations. High 132- OH-BPME and 8-(alpha) -bo-Zn-Pc uptakes were recorded in the parenchymatous organs (liver, lung), with 8-(alpha) -bo-Zn-Pc long retention. The malignant tissues accumulated 132-OH- BPME of more than 20 folds than 8-(alpha) -bo-Zn-Pc at all incubation times. 8-(alpha) -bo-Zn-Pc concentrations in the skin and the muscle were lower than 132-OH-BPME concentrations at any interval period, but also, the 8- (alpha) -bo-Zn-Pc retained longer until 168 h. PDT with 132-OH-BPME will be more effective than with 8-(alpha) -bo- Zn-Pc where it has more concentrations in the malignant tissues.
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M. Samy Ismail, Cathrin Dressler, Beate Roeder, H. Weitzel, and Hans-Peter Berlien "Pharmacokinetics evaluation of 132-hydroxy-bacteriopheophorbid-a methyl ester and octa-alpha-butyloxy-zinc phthalocyanine for future application in PDT", Proc. SPIE 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III, (29 December 1997); https://doi.org/10.1117/12.297821
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KEYWORDS
Photodynamic therapy
Lung
Tissues
Absorption spectroscopy
Liver
Skin
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