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29 December 1997 Phenomenon of PDT-induced post-irradiation apoptosis in biological liquids cancer cells using sulphonated phthalocyanine aluminum photosensitizer
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Abstract
Discovered during last year's phenomenon of PDT-induced apoptosis (programmed cell destruction) in cell culture immediately after light irradiation using phthalocyanine photosensitizers can be used for treatment of cancer. Experiments were carried out on mice with ascites. Ascitic liquid with the added photosensitizer was irradiated by light source with wavelength 660 - 680 nm and used according to ex vivo procedure. Actuation and development of apoptosis process in ascitic liquid were estimated by cytomorphological tests. It has been observed the phenomenon of growth of relative fraction of cells damage level expressed mainly as apoptosis after PDT procedure ex vivo. We suggest to call this phenomenon as PDT-induced post-irradiation apoptosis (PIP- apoptosis). Dependence between level of expressing of PIP- apoptosis and sulphonated phthalocyanine aluminum photosensitizer (Photosense) concentration at used photosensitizer concentrations has not been found out.
© (1997) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Alexandre Yu. Douplik, Victor B. Loschenov, Georgy N. Vorozhtsov, Eugenia A. Kogan, Michael Kusin, Y. Ablitsov, and O. S. Ilyina "Phenomenon of PDT-induced post-irradiation apoptosis in biological liquids cancer cells using sulphonated phthalocyanine aluminum photosensitizer", Proc. SPIE 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III, (29 December 1997); https://doi.org/10.1117/12.297793
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