29 December 1997 Photodynamic therapy of recurrent tumors of oropharyngeal area as an out-patient procedure
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Abstract
The frequency of tumor recurrences after conventional treatment is high (up to 35 - 60% depending on the stage of tumor progression) and the efficacy of conventional treatment of tumor recurrences and/or tumor 'remains' is low. In the State Research Center for Laser Medicine photodynamic therapy (PDT) is being applied to the patients with recurrent tumors of tongue, oral mucose and lower lip since 1992. In the last five years 26 patients with morphologically proven recurrent tumors of tongue, oral mucose and lower lip have been treated with PDT. The age of the patients ranged 50 to 84. Russian photosensitizers were used: photoheme (haematoperphyrine derivative in dosage 1.5 - 5.0 mg/kg body weight) and photosense (sulphonated aluminum phthalocyanine in dosage 0.7 - 1.5 mg/kg body weight) and Russian lasers. No complications of photosensitizer administration have been noted. In all cases PDT was carried out as an out-patient procedure. Therapeutic effect has been achieved in 22 patients. Complete resorption of tumors took place in 15 cases (57.7%). In 7 cases (26.9%) partial resorption of tumors took place. In four cases tumor resorption was less than 50% of elementary size. These results have been estimated as 'no response.' Mentioned results allow one to estimate PDT as a stand-alone technique for treating recurrent tumors of oropharyngeal localization. Although the results in some patients were estimated as 'no response,' there were no cases of absolute tumor resistance to PDT. The ability to perform PDT on the out-patients basis makes this technique cost-effective.
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Eugeny Ph. Stranadko, Max I. Garbusov, Nikolai A. Markitchev, Michail V. Riabov, "Photodynamic therapy of recurrent tumors of oropharyngeal area as an out-patient procedure", Proc. SPIE 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III, (29 December 1997); doi: 10.1117/12.297810; https://doi.org/10.1117/12.297810
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