29 December 1997 Systemic estimation of the effect of photodynamic therapy of cancer
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Abstract
The effects of photodynamic therapy (PDT) of cancer needs objective estimation and its unification in experimental as well as in clinical studies. They must include not only macroscopical changes but also the complex of following morphological criteria: (1) the level of direct tumor damage (direct necrosis and apoptosis); (2) the level of indirect tumor damage (ischemic necrosis); (3) the signs of vascular alterations; (4) the local and systemic antiblastome resistance; (5) the proliferative activity and malignant potential of survival tumor tissue. We have performed different regimes PDT using phthalocyanine derivatives. The complex of morphological methods (Ki-67, p53, c-myc, bcl-2) was used. Obtained results showed the connection of the tilted morphological criteria with tumor regression.
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Eugenia A. Kogan, Eugenia A. Kogan, Gennadii A. Meerovich, Gennadii A. Meerovich, Nadezgda L. Torshina, Nadezgda L. Torshina, Victor B. Loschenov, Victor B. Loschenov, Anna I. Volkova, Anna I. Volkova, Anna M. Posypanova, Anna M. Posypanova, } "Systemic estimation of the effect of photodynamic therapy of cancer", Proc. SPIE 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III, (29 December 1997); doi: 10.1117/12.297803; https://doi.org/10.1117/12.297803
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