1 January 1998 Multichannel near-infrared spectroscopy: data evaluation by means of time series analysis
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We used near infrared spectroscopy (NIRS) to study non- invasively changes in cerebral hemoglobin oxygenation during performance of a verbal fluency task in healthy volunteers (n equals 19). We used a multichannel system combining six commercially available NIRS devices (NIRO-500, Hamamatsu Photonics) that allows measurements over the left and right frontal, parietal and occipital cortex simultaneously. We described the NIRS variables both in the time- and frequency-domain using digital signal processing. In the time-domain we measured the blood flow response by calculation of concentration changes for oxygenated and deoxygenated hemoglobin (HbO2, HbR) and their latency to stimulus variations. We applied frequency selective filters and found an increase of the global signal variability during cognitive stimulation. These effects can be visualized by spectral analysis. The powerspectras of the optical signal varied clearly with rest and activity states and showed a different spectral distribution over the frontal as compared to the parietal cortex.
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R. Stoermer, R. Stoermer, F. Mueller-Spahn, F. Mueller-Spahn, Christoph Hock, Christoph Hock, } "Multichannel near-infrared spectroscopy: data evaluation by means of time series analysis", Proc. SPIE 3194, Photon Propagation in Tissues III, (1 January 1998); doi: 10.1117/12.301046; https://doi.org/10.1117/12.301046

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