1 January 1998 NIRS and indocyanine-green-determined muscle blood flow during exercise in humans
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Abstract
We present a method for determination of muscle blood flow (MBF) using near infrared spectroscopy (NIRS) with indocyanine green (ICG) as the tracer. MBF was quantified using the integrated arterial [ICG] and the accumulation of ICG in muscle. MBF was determined together with ICG-assessed cardiac output (CO) at rest and during incremental cycling. To further modify CO, the same work loads were performed after cardio-selective beta blockade by metoprolol. In one subject both MBF (9 to 110 ml (DOT) 100 g-1 (DOT) min-1) and CO increased linearly with work rate (8 to 19 l (DOT) min-1). Under beta blockade, both the increase in MBF and CO were lower: 5 to 70 ml (DOT) 100 g-1 (DOT) min-1 and 5 to 161 DOT min-1, respectively. During exercise with and without beta blockade, MBF increased with work load to represent a larger proportion of CO. Also, NIRS could detect an attenuated increase in MBF manifest by the restrained CO during leg exercise after cardio-selective beta blockade. Both observations indicate that NIRS detection of indocyanine green provides an estimate of muscle blood flow over the range from rest to intense exercise.
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Robert Boushel, Robert Boushel, Kojiro Ide, Kojiro Ide, Hasse Moller-Sorensen, Hasse Moller-Sorensen, Alvito Fernandes, Alvito Fernandes, Frank Pott, Frank Pott, Niels H. Secher, Niels H. Secher, } "NIRS and indocyanine-green-determined muscle blood flow during exercise in humans", Proc. SPIE 3194, Photon Propagation in Tissues III, (1 January 1998); doi: 10.1117/12.301045; https://doi.org/10.1117/12.301045
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