14 January 1998 Application of optical diffusion theory to transcutaneous bilirubinometry
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Abstract
Neonatal hyperbilirubinemia affects more than half of the newborns and represents a potentially serious condition due to the toxicity of bilirubin to the central nervous system. A precise non-invasive technique for the monitoring of bilirubin concentration is desirable for the treatment of icteric babies. Transcutaneous bilirubinometry based on optical reflectance spectra is complicated by the superposition of the spectral absorption properties of melanin and haemoglobin with those of bilirubin. Diffusion theory forms a suitable model for the description of light propagation in tissue. In this treatment, an inverse diffusion approach is developed to measure bilirubin concentration in tissue by means of the reflectance spectrum. First results of its application to in vivo measurements are encouraging.
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Thorsten Spott, Lars Othar Svaasand, R. E. Anderson, P. F. Schmedling, "Application of optical diffusion theory to transcutaneous bilirubinometry", Proc. SPIE 3195, Laser-Tissue Interaction, Tissue Optics, and Laser Welding III, (14 January 1998); doi: 10.1117/12.297907; https://doi.org/10.1117/12.297907
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KEYWORDS
Absorption

Skin

Blood

Diffusion

Scattering

Tissue optics

Reflectivity

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