29 December 1997 Monte Carlo investigations of the wavelength dependence of light transport through turbid media
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Elastic-scattering spectroscopy examines the wavelength dependence of light that has passed through a small volume of tissue. Measurements are typically made by placing two optical fibers on the surface of the tissue to be examined. The analysis of these measurements to obtain quantitative information about scattering and absorption is important to many biomedical applications such as cancer diagnosis and measurement of bilirubin concentrations. For fiber separations large enough for the diffusion approximation to be valid, this is straight forward. However, for clinical applications such as those listed above, the separation is too small for the diffusion approximation to be applicable. To obtain insight into the question of how scattering and absorption changes affect the wavelength dependence of the elastic-scatter signal Monte Carlo simulations have been used. First, it is shown that the Monte Carlo simulations and elastic-scatter measurements of polystyrene spheres agree quite well. Monte Carlo simulations are then used to investigate how particle size and concentration affect the elastic-scatter signal. It is found that the concentration has very little effect of the wavelength dependence, but that the size of the scattering particles does affect the wavelength dependence. In general, the signal decreases more rapidly as a function of wavelength for smaller particles.
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Judith R. Mourant, Judith R. Mourant, "Monte Carlo investigations of the wavelength dependence of light transport through turbid media", Proc. SPIE 3197, Optical Biopsies and Microscopic Techniques II, (29 December 1997); doi: 10.1117/12.297956; https://doi.org/10.1117/12.297956

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