Analgesic effect of low-power infrared laser radiation in rats

Janina Mrowiec; Aleksander Sieron; Andrzej Plech; Grzegorz Cieslar; Tomasz Biniszkiewicz; Ryszard Brus

doi:10.1117/12.297992

22 December 1997 Analgesic effect of low-power infrared laser radiation in rats

Janina Mrowiec, Aleksander Sieron, Andrzej Plech, Grzegorz Cieslar, Tomasz Biniszkiewicz, Ryszard Brus

Proceedings Volume 3198, Effects of Low-Power Light on Biological Systems; (1997) https://doi.org/10.1117/12.297992
Event: BiOS Europe '97, 1997, San Remo, Italy

Abstract

The aim of the study was to confirm the analgesic effect of low-power laser radiation with a tail-immersion test and check if nitric oxide is involved in laser radiation-induced analgesia in rats. The experiment was performed on male Wistar rats. On the day of experiment the scull of rats was exposed to IR laser radiation for 10 min and antinociceptive effect was determined by means of tail immersion test. The experiments were also performed on 1-NAME and methylene blue pretreated rates, in which both chemicals were administered into right lateral brain ventricle. The results were compared to the ones obtained in the control group in which sham irradiation was made. It was observed that 10 min. exposure to low-power IR laser radiation induced only transient distinct antinociceptive effect in rats. This effect was prevented by ICV. injection of 1-NAME, an inhibitor of nitric oxide synthase and methylene blue, an inhibitor of soluble guanylate cyclase. It seems that nitric oxide is involved in mechanism of low-power laser radiation- induced analgesia.

Citation Download Citation

Janina Mrowiec, Aleksander Sieron, Andrzej Plech, Grzegorz Cieslar, Tomasz Biniszkiewicz, and Ryszard Brus "Analgesic effect of low-power infrared laser radiation in rats", Proc. SPIE 3198, Effects of Low-Power Light on Biological Systems, (22 December 1997); https://doi.org/10.1117/12.297992

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