Optical fiber-based sensor instrumentation has been used extensively for the measurement of physical observables including strain, temperature and chemical changes in smart materials and smart structures, and have been integrated with MEMS devices to provide multi-measurement capability along the length of a fiber link or network. This plenary paper briefly outlines recent developments in such optical fiber sensor instrumentation. Fiber optic sensors are small in size, immune to electromagnetic interference and can be easily integrated with existing optical fiber hardware and components that have been developed primarily for use in the larger telecommunications market. Such sensors can be easily multiplexed, resulting in networks that can be used for the health monitoring of large structures, or the real-time monitoring of structural parameters required for structural analysis and control. This paper briefly describes and compares three current fiber sensor configurations that use Fabry-Perot interferometry and fiber Bragg gratings (FBG) and long-period grating (LPG) elements to monitor strain, temperature and other parameters. Extensive details concerning additional related work and field test results and applications are discussed in the references.