Critical temperature transitions in laser-mediated cartilage reshaping

Brian Jet-Fei Wong M.D.; Thomas E. Milner; Hong H. Kim; Sergey A. Telenkov; Clifford Chew; Timothy C. Kuo; Derek J. Smithies; Emil N. Sobol; J. Stuart Nelson M.D.

doi:10.1117/12.312284

1 July 1998 Critical temperature transitions in laser-mediated cartilage reshaping

Brian Jet-Fei Wong M.D., Thomas E. Milner, Hong H. Kim, Sergey A. Telenkov, Clifford Chew, Timothy C. Kuo, Derek J. Smithies, Emil N. Sobol, J. Stuart Nelson M.D.

Author Affiliations +

Proceedings Volume 3245, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VIII; (1998) https://doi.org/10.1117/12.312284
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States

Abstract

In this study, we attempted to determine the critical temperature [T_c] at which accelerated stress relaxation occurred during laser mediated cartilage reshaping. During laser irradiation, mechanically deformed cartilage tissue undergoes a temperature dependent phase transformation which results in accelerated stress relaxation. When a critical temperature is attained, cartilage becomes malleable and may be molded into complex new shapes that harden as the tissue cools. Clinically, reshaped cartilage tissue can be used to recreate the underlying cartilaginous framework of structures such as the ear, larynx, trachea, and nose. The principal advantages of using laser radiation for the generation of thermal energy in tissue are precise control of both the space-time temperature distribution and time- dependent thermal denaturation kinetics. Optimization of the reshaping process requires identification of the temperature dependence of this phase transformation and its relationship to observed changes in cartilage optical, mechanical, and thermodynamic properties. Light scattering, infrared radiometry, and modulated differential scanning calorimetry (MDSC) were used to measure temperature dependent changes in the biophysical properties of cartilage tissue during fast (laser mediated) and slow (conventional calorimetric) heating. Our studies using MDSC and laser probe techniques have identified changes in cartilage thermodynamic and optical properties suggestive of a phase transformation occurring near 60 degrees Celsius.

Citation Download Citation

Brian Jet-Fei Wong M.D., Thomas E. Milner, Hong H. Kim, Sergey A. Telenkov, Clifford Chew, Timothy C. Kuo, Derek J. Smithies, Emil N. Sobol, and J. Stuart Nelson M.D. "Critical temperature transitions in laser-mediated cartilage reshaping", Proc. SPIE 3245, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VIII, (1 July 1998); https://doi.org/10.1117/12.312284

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