Low-dose psoralen and UVA (PUVA) therapy-enhanced arterial shrinkage after balloon angioplasty in rabbits

Jop Perree; Ton G. J. M. van Leeuwen; Evelyn Velema; Cornelius Borst M.D.

doi:10.1117/12.312321

1 July 1998 Low-dose psoralen and UVA (PUVA) therapy-enhanced arterial shrinkage after balloon angioplasty in rabbits

Jop Perree, Ton G. J. M. van Leeuwen, Evelyn Velema, Cornelius Borst M.D.

Proceedings Volume 3245, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VIII; (1998) https://doi.org/10.1117/12.312321
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States

Abstract

Restenosis after balloon angioplasty is caused by both intimal hyperplasia and arterial shrinkage (constrictive remodeling). Previous studies have indicated the inhibitory effect of photodynamic therapy on intimal hyperplasia development after angioplasty. The potential of a photoactivation regime (Psoralen + UVA irradiation: PUVA), which does not cause unwanted systemic side effects, for the prevention of both intimal hyperplasia formation and constrictive remodeling following balloon dilation was explored in the present study. In the rabbit iliac artery, balloon dilation followed by PUVA- therapy at a radiant exposure of 1 J/cm² was performed (n equals 10). Control balloon dilation was performed in the contralateral arteries (n equals 10). After 4 weeks of survival, angiographic lumen renarrowing was determined in terms of intimal hyperplasia and constrictive remodeling. Late loss, but not intimal hyperplasia, was significantly larger in the PUVA group as compared to the control group (p less than 0.05). This difference in angiographic lumen loss can only be attributed to the difference in constrictive remodeling (arterial shrinkage). Thus, PUVA-therapy did not prevent intimal hyperplasia following balloon dilation. PUVA-therapy even enhanced luminal narrowing by augmented constrictive arterial remodeling.

Citation Download Citation

Jop Perree, Ton G. J. M. van Leeuwen, Evelyn Velema, and Cornelius Borst M.D. "Low-dose psoralen and UVA (PUVA) therapy-enhanced arterial shrinkage after balloon angioplasty in rabbits", Proc. SPIE 3245, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VIII, (1 July 1998); https://doi.org/10.1117/12.312321

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KEYWORDS

Angiography

Arteries

Injuries

Photodynamic therapy

Ultraviolet radiation

Blood

Cardiology

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