The subject of this work follows changes of the sIgA and albumin levels in the saliva of 48 patients treated after the extraction of their lower molars with either diode or He-Ne biostimulatory laser, using different modulatory frequencies (5 Hz, 292 Hz, 9000 Hz). The results were compared to the sIgA and albumin levels in the saliva of the control, i.e. not- treated group. For the tests radial immunodiffusion (RID) method was used (commercial RID kit of the Binding Site, Birmingham, Great Britain). Appropriately chosen laser beam modulatory frequency should influence the increase in the sIgA and albumin levels against the base level. In our study, this hypothesis was confirmed in the group treated with the frequency of 292 Hz and 9000 Hz (both diode GaAIAs, 670 nm, red, 20 mW, energy density 1.5 Jcm2) on albumin levels and 9000 Hz on sIgA levels. The changes of the levels of the watched markers versus the control group were at this frequencies (292 Hz and 9000 Hz) statistically significant. At the others used frequencies (5 Hz diode laser and 5 Hz He-Ne laser) the changes of the levels of the watched markers versus control group were statistically insignificant. The aim of this study was to contribute to the evaluation of specific modulatory frequencies (5 Hz, 292 Hz, 9000 Hz) for therapeutical use in a given pathological case of the oral cavity. We can conclude that using frequency 9000 Hz had best immunomodulatory effect.