Cancer treatment by photodynamic therapy combined with NK-cell-line-based adoptive immunotherapy

Mladen Korbelik; Jinghai Sun

doi:10.1117/12.308148

13 May 1998 Cancer treatment by photodynamic therapy combined with NK-cell-line-based adoptive immunotherapy

Mladen Korbelik, Jinghai Sun

Proceedings Volume 3254, Laser-Tissue Interaction IX; (1998) https://doi.org/10.1117/12.308148
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States

Abstract

Treatment of solid cancers by photodynamic therapy (PDT) triggers a strong acute inflammatory reaction localized to the illuminated malignant tissue. This event is regulated by a massive release of various potent mediators which have a profound effect not only on local host cell populations, but also attract different types of immune cells to the treated tumor. Phagocytosis of PDT-damaged cancerous cells by antigen presenting cells, such as activated tumor associated macrophages, enables the recognition of even poorly immunogenic tumors by specific immune effector cells and the generation of immune memory populations. Because of its inflammatory/immune character, PDT is exceptionally responsive to adjuvant treatments with various types of immunotherapy. Combining PDT with immuneactivators, such as cytokines or other specific or non-specific immune agents, rendered marked improvements in tumor cures with various cancer models. Another clinically attractive strategy is adoptive immunotherapy, and the prospects of its use in conjunction with PDT are outlined.

Citation Download Citation

Mladen Korbelik and Jinghai Sun "Cancer treatment by photodynamic therapy combined with NK-cell-line-based adoptive immunotherapy", Proc. SPIE 3254, Laser-Tissue Interaction IX, (13 May 1998); https://doi.org/10.1117/12.308148

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